Manchester United are without eight players for the Champions League semi-final first leg against AC Milan.
Rio Ferdinand has a groin injury and joins fellow defenders Gary Neville, Nemanja Vidic, Mikael Silvestre and Craig Cathcart on the sidelines.
That leaves Patrice Evra, Wes Brown, John O'Shea and Gabriel Heinze as United's only fit defenders.
Midfielders Ji-Sung Park and Kieran Richardson will also miss the game, along with striker Louis Saha.
United boss Sir Alex Ferguson said: "We're down to the bare bones. We are playing with 12 players.
"It's not a time for feeling sorry for ourselves. It's time to show what we are made of. It's been well documented in the history of our football club that we do it the hard way anyway.
"We have to restore the players' energies for Tuesday because it is a massive game for them and it's a game they should enjoy."
In contrast to United, AC Milan were able to rest a host of players for their league match on Saturday.
Manager Carlo Ancelotti has a virtually fully-fit squad available, with striker Alberto Gilardino returning after suspension.
Keeper Dida has been included in the squad but is a doubt with a shoulder injury, while Ronaldo is cup-tied.
Ancelotti was encouraged by the news that Ferdinand will not feature at Old Trafford but is wary of United's attacking threat.
"Ferdinand is a very important player for their defence," he said.
"But we will have to be careful and keep possession of the ball but that could be a two-edged sword, because if we do not do well our opponents could hit us on the counter-attack."